You can test .NET applications without any special preparations. You can also access individual objects of .NET applications, their internal properties and methods from your tests.
However, in certain cases, you need to prepare your .NET application before testing it:
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To test a .NET application launched from a network share, run the application with the Full Trust permission.
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To test a .NET application launched from a web server using Internet Explorer and no-touch deployment, run the application with the Full Trust permission.
To learn how to run .NET applications with the Full Trust permission, see —
Preparing Network and No-Touch Deployment .NET Applications for Testing