You can enhance your testing efforts with TestComplete by using the following APIs:
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Test Runner REST API - Enables you to control projects and test runs from third-party tools, for instance, from continuous integration (CI) systems.
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Test Engine REST API - Enables you to access the test engine from third-party tools. You can access tested applications, their objects, properties and methods, and simulate user actions on the tested applications.
 
Related Materials
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If you are interested in API testing, you can use ReadyAPI, another product by SmartBear for functional and security API testing:
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To include HTTP requests to your automated tests in TestComplete, you can use the
aqHttpobject and its methods or the Send Request operation: 

About ReadyAPI